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• Blood is composed of plasma (water, metabolites, wastes, salts, and proteins), red blood cells, white blood cells, and platelets.

• Red blood cells transport oxygen. White blood cells help defend the body against disease. Platelets are essential to the formation of a blood clot.

• Blood clotting occurs when platelets release a clotting protein, which causes a clotting reaction to occur. A fibrin net forms, trapping blood cells and platelets.

• Human blood can be grouped into four types—A, B, AB, and O—based on proteins on the surface of red blood cells. Another antigen called Rh factor, is sometimes

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