Hiv

/Viral RNA

Viral DNA

Reverse transcriptase

/Viral RNA

Receptors

Cell

Host chromosome cell \

Viral protein

Reverse transcriptase w/

Viral DNA

Viral DNA

Viral protein

Viral DNA

I—Nucleus

I—Nucleus

Researchers working on a cure for AIDS are studying the HIV life cycle for weak points to target with new therapies. Because normal human cells do not make reverse transcriptase, this enzyme provided the first target for a chemical therapy. For example, the drug azidothymidine (uh-ZIE-doh-THIE-muh-DEEN) (AZT) inhibits the ability of reverse transcriptase to make a DNA copy of the viral RNA. Another class of drugs, called protease inhibitors, blocks the synthesis of new viral capsids. Combinations of protease inhibitors and AZT have been shown to be helpful in slowing the progression of HIV infection to full-blown AIDS.

www.scilinks.org Topic: AIDS Virus Keyword: HM60028

www.scilinks.org Topic: AIDS Virus Keyword: HM60028

Maintained by the ,i j National Science I. \ J\ .3. Teachers Association

Maintained by the ,i j National Science I. \ J\ .3. Teachers Association

Viruses and Cancer

Cancer results when cells divide at an uncontrolled rate and form a tumor that invades surrounding tissue. Some viruses contain viral oncogenes, genes that cause cancer by blocking the normal controls on cell reproduction. Other viruses cause cancer because the viral DNA inserts itself into a host's chromosome near a proto-oncogene, which usually controls cell growth. The proto-oncogene is converted to an oncogene. Human papillomavirus (HPV) can cause cervical cancer, and hepatitis B virus can cause liver cancer. Other viruses, such as human T-lymphotrophic virus (HTLV), can cause leukemia, and Epstein-Barr virus (EBV) can cause Burkitt's lymphoma, a malignant tumor of the jaw.

Was this article helpful?

0 0
Sirens Sleep Solution

Sirens Sleep Solution

Discover How To Sleep In Peace And Harmony In A World Full Of Uncertainty And Dramatically Improve Your Quality Of Life Today! Finally You Can Fully Equip Yourself With These “Must Have” Tools For Achieving Peace And Calmness And Live A Life Of Comfort That You Deserve!

Get My Free Ebook


Post a comment