Renal

In a rat model of mesangiolysis, vascular delivery of SPIO-labeled MSCs could be detected in both the liver and the kidney (Bos et al., 2004; Hauger et al., 2006). In the case of intravenous injection, homing to the cortical area could be tracked using MR microscopy at 9.4 T (Figure 6.9). Unfortunately, despite detection of intravenously delivered cells in the liver, the cells could not be

Figure 6.9. a Ex vivo sagittal three-dimensional T|-weighted (110/15.7, flip angle of 30°) 9.4 T MR images of (a) control and (b) pathologic kidney 6 days after intravenous injection of 107-labeled MSCs (the upper pole is oriented left). In a, no signal intensity decrease is noted. In b, the corticomedullary differentiation is absent and distinct areas of cortical signal intensity decrease are present in the superior and superior midportion. b Ex vivo sagittal three-dimensional T2*-weighted (110/15.7, flip angle of 30°) 9.4 T MR images of (a) control and (b) pathologic kidney 6 days after intravenous injection of 107-labeled MSCs (the upper pole is oriented left). In a, no signal intensity decrease is noted. In b, the corticomedullary differentiation is absent and distinct areas of cortical signal intensity decrease are present in the superior and superior midportion (arrows) poles. Reprinted from Hauger et al. (2006). Reproduced with permission from the Radiological Society of North America.

Figure 6.9. a Ex vivo sagittal three-dimensional T|-weighted (110/15.7, flip angle of 30°) 9.4 T MR images of (a) control and (b) pathologic kidney 6 days after intravenous injection of 107-labeled MSCs (the upper pole is oriented left). In a, no signal intensity decrease is noted. In b, the corticomedullary differentiation is absent and distinct areas of cortical signal intensity decrease are present in the superior and superior midportion. b Ex vivo sagittal three-dimensional T2*-weighted (110/15.7, flip angle of 30°) 9.4 T MR images of (a) control and (b) pathologic kidney 6 days after intravenous injection of 107-labeled MSCs (the upper pole is oriented left). In a, no signal intensity decrease is noted. In b, the corticomedullary differentiation is absent and distinct areas of cortical signal intensity decrease are present in the superior and superior midportion (arrows) poles. Reprinted from Hauger et al. (2006). Reproduced with permission from the Radiological Society of North America.

detected in vivo in the kidney following arterial delivery (Hauger et al., 2006). This indicates that the higher signal to noise and resolution available from high-field MR scanners may be necessary to detect homing in some organ systems similar to the damaged kidney following intravenous delivery of SPIO-labeled cells (Hauger et al., 2006).

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