Sputum Cytology and Advanced Sputum Analysis Techniques

In screening studies, the sensitivity of sputum cytology for detecting lung cancer is approximately 20 to 30% and the specificity is approximately 98% [6,47,53]. Improvement in sensitivity can be achieved by adherence to proper techniques for collection, processing, and interpretation of samples [48]. Sputum cytology demonstrates the highest sensitivity for squamous cell carcinoma and the lowest yield for adenocarcinoma [21].

In recent years, there have been several exciting advances in sputum analysis techniques, most notably the development of automated analysis of sputum specimens for biomarkers [49,50-56]. This technology capitalizes on advances in our understanding of the molecular events that lead to lung cancer. In the future, it is likely that a panel of biomarkers (Table 4) will be used to identify the early clonal phase of lung cancer, thus allowing detection of lung cancers at a very early stage [52]. Importantly, biomarker characterization may also allow for targeted treatment of early lung cancer [52].

The Smoker's Sanctuary

The Smoker's Sanctuary

Save Your Lungs And Never Have To Spend A Single Cent Of Ciggies Ever Again. According to a recent report from the U.S. government. Centers for Disease Control and Prevention, more than twenty percent of male and female adults in the U.S. smoke cigarettes, while more than eighty percent of them light up a cigarette daily.

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