In screening studies, the sensitivity of sputum cytology for detecting lung cancer is approximately 20 to 30% and the specificity is approximately 98% [6,47,53]. Improvement in sensitivity can be achieved by adherence to proper techniques for collection, processing, and interpretation of samples . Sputum cytology demonstrates the highest sensitivity for squamous cell carcinoma and the lowest yield for adenocarcinoma .
In recent years, there have been several exciting advances in sputum analysis techniques, most notably the development of automated analysis of sputum specimens for biomarkers [49,50-56]. This technology capitalizes on advances in our understanding of the molecular events that lead to lung cancer. In the future, it is likely that a panel of biomarkers (Table 4) will be used to identify the early clonal phase of lung cancer, thus allowing detection of lung cancers at a very early stage . Importantly, biomarker characterization may also allow for targeted treatment of early lung cancer .
Was this article helpful?
Stop Nicotine Addiction Is Not Easy, But You Can Do It. Discover How To Have The Best Chance Of Quitting Nicotine And Dramatically Improve Your Quality Of Your Life Today. Finally You Can Fully Equip Yourself With These Must know Blue Print To Stop Nicotine Addiction And Live An Exciting Life You Deserve!