The COXProstaglandin Pathway and Colorectal Cancers

Early reports demonstrated elevated levels of prostaglandins in colorectal cancer compared to normal mucosa15-17 and more recently, a more comprehensive study showed a significant increase in PGE2 in 21 surgically excised colorectal cancers.18 Stemming from this observed increase in prostaglandin synthesis in colorectal cancer, recent studies have analyzed the levels of the COX enzymes in colorectal cancer. Eberhart et al19 measured COX-1 and COX-2 mRNA levels in adenocarcinomas and the paired normal mucosa of 14 surgical patients with cancers classified as Dukes' Stage B to D. Low to undetectable levels of COX-2 mRNA were observed in the normal mucosa. However, COX-2 expression was apparent in 12 of the 14 carcinomas (86%). This increase in COX-2 varied from a 2- to 50-fold elevation compared to normal mucosa and the degree of upregulation did not appear to correlate cyclooxygenase


Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment