Development of the Angiogenic Phenotype in Tumors

Although angiogenesis is essential to both tumor progression and the development of metastases, many of the molecules and mechanisms that are involved in the angiogenic process still have not been elucidated. Recently, in vivo models of carcinogenesis have helped to define better the temporal relationship between development of the angiogenic pheno-type and tumor progression. Three models have been successful in investigating this relationship and involve overexpression of either the SV40 T antigen oncogene under control of the insulin gene promoter in RIP-Tag transgenic mice which develop pancreatic islet cell cancers, the bovine papillomavirus genome in BPV1.69 transgenic mice which develop dermal fibrosarcomas, or the human papillomavirus-16 oncogene under control of the

Molecular Mechanisms in Gastrointestinal Cancer, edited by B. Mark Evers. ©1999 R.G. Landes Company.

Fig. 6.1. The process of tumor angiogenesis. In a complex series of events, angiogenic factors provide a signal for quiescent mature blood vessels to develop new vascular sprouts that subsequently undergo remodeling and maturation.

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