Gastric Cancer p53

By far, p53 appears to be the most common cancer gene altered in gastric neoplasms, regardless of histological classification or staging. Abnormalities of the p53 gene, which occur as missense mutations, frame shifts, and allelic loss,68 are found in at least 60 of gastric cancers and 30 of gastric adenomas.69,70 Lesions in p53 appear to occur early in the adenoma-carcinoma sequence and may play an important role in gastric cancer expansion even from early stages.71 The discrete epidemiological...