Precision

Precision is the determination of how close the repeated measurements of the same concentration are to one another. A minimum of three analyte concentrations that span the standard curve should be assessed, and at least five determinations or replicates should be conducted for each concentration. Precision is calculated as the coefficient of variation (% CV) following repeated measurements.

Precision (% CV)=(standard deviation/mean) • 100 (see Table 1)

The acceptance criteria for precision is a coefficient of variation of ±15%, but at the LLOQ a precision of ±20% is permissible. For the determination of both accuracy and precision, within-day (within-run) and between-day (between-run) determinations are made.

Was this article helpful?

0 0

Post a comment