LCtandem Mass Spectrometry

Currently, the most widely used analytical technology is LC/MS/MS. Traditionally, these systems were cumbersome and difficult to use, but recent advances in technology and automation have made LC/MS/MS systems the stalwart of current analytical methodologies. LC/MS/MS depends on HPLC to separate the analyte from other matrix constituents as described in the preceding section, but the use of tandem mass spectrometry allows for the detection of very small quantities of drug, in addition to generating information about the chemical structure of the analyte which allows for analyte identification.

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