If suspect, commence antituberculous treatment Recommended treatment programme: Normal regime:

Isoniazid (300 mg daily) Rifampicin (600 mg daily) —

2 months

Pyrazinamide (15-30 mg/kg daily)

Isoniazid Rifampicin

6 months

Drug resistance suspected due to previous antituberculous therapy, e.g.

- Third World countries

- History of previous infection.

-» Add a fourth drug - streptomycin (1 g daily) or ethambutol (25 mg/kg daily). Isoniazid and pyrazinamide penetrate meninges well; other drugs penetrate less well especially when the inflammation begins to settle.

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