Raised Intracranial Pressure

The skull is basically a rigid structure. Since its contents - brain, blood and cerebrospinal fluid (CSF) - are incompressible, an increase in one constituent or an expanding mass within the skull results in an increase in intracranial pressure (ICP) - the 'Monro-Kellie doctrine'.

Compensatory mechanisms for an expanding intracranial mass lesion:

Immediate / ^" ^ CSF volume - CSF outflow to the lumbar theca \ 2. I Cerebral blood volume - Delayed - 3. j Extracellular fluid

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