Radionucleotide Imaging

Single photon emission computed tomography (SPECT) (contd)

The normal scan - HMPAO (10 mm resolution) The tomogram is examined in conjunction with structural imaging (CT or MRI) to aid interpretation.

- Assessment of blood flow changes in DEMENTIA

Blood flow is generally reduced, especially in temporal and parietal lobes

- Evaluation of patients with intractable EPILEPSY of temporal lobe origin

Normal subject

Scan of temporal lobe showing symmetrical pattern of blood flow more prominent in grey matter

Patient with temporal lobe epilepsy

An interictal scan shows reduced flow throughout the temporal lobe

An ictal scan (i.e. HMPAO injectcd during the seizure) shows a marked hyperperfusion of the temporal lobe

The plane of scan lies in the same axis as the temporal lobe

Clinical application

- Detection of early ischaemia in OCCLUSIVE and HAEMORRHAGIC CEREBROVASCULAR DISEASE

Absence of blood flow corresponds with area of infarction and tissue loss seen on structural imaging.

Such findings aid localisation of the epileptic focus and selection of patients for surgical treatment.

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