Patterns Of Injury

Damage may occur to: axon, myelin sheath, cell body, supporting connective tissue and nutrient blood supply to nerves. Three basic pathological processes occur.

wallerian degeneration segmental ' demyelinatio

Degeneration of axon distally following its interruption

Degeneration of axon distally following its interruption

Distal to injury the axon disintegrates and the myelin breaks up into globules.

Approximation of nerve ends result in regeneration. The basement membrane of the Schwann cell survives and acts as a skeleton along which the axon regrows.

segmental ' demyelinatio

distal axonal degeneration

Scattered destruction of the myelin sheath occurs without axonal damage.

The primary lesion affects the Schwann cell. Prognosis for recovery is good because the muscle is not denervated.

Damage to the cell body or to the axon will affect the viability of the axon which will 'die back' from the periphery. Loss of the myelin sheath occurs as a secondary event.

Recovery is slow because the axon must regenerate. When the cell body is destroyed reinnervation of muscle can only occur from surrounding nerves.

Was this article helpful?

0 0
Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment