Myasthenia gravis

Myasthenia gravis is a disorder of neuromuscular transmission characterised by:

- Weakness and fatiguing of some or all muscle groups.

- Weakness worsening on sustained or repeated exertion, or towards the end of the day, relieved by rest.

This condition is a consequence of an autoimmune destruction of the NICOTINIC POSTSYNAPTIC RECEPTORS FOR ACETYLCHOLINE.

Myasthenia gravis is rare, with a prevalence of 5 per 100 000. The increased incidence of autoimmune disorders in patients and first degree relatives and the association of the disease with certain histocompatibility antigens (HLA) - B7, B8 and DR2 - suggests an IMMUNOLOGICAL BASIS.

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