Multiple sclerosis

Diagnostic criteria have been proposed (Poser Committee 1983). These were primarily conceived for research and clinical trials of therapy but are also of use to the clinician.

CLINICALLY DEFINITE

-Two attacks of symptoms

LABORATORY SUPPORTED DEFINITE

CLINICALLY PROBABLE

LABORATORY SUPPORTED PROBABLE

clinical signs or investigative evidence of two lesions.

clinical signs or investigative evidence of one lesion. Abnormal CSF (oligoclonal bands).

clinical signs or investigative evidence of one lesion.

abnormal CSF (oligoclonal bands).

(Modified from Poser 1983 Annals of Neurology 13:227-231.)

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