If complex large or antigen in excess will lodge in 'gaps' between endothelial cells in vessel
Results in production of lysoenzymcs and destruction of vessel wall with haemorrhage and fibrinoid necrosis
Indirect immunofluorescent microscopy on biopsy material will demonstrate the presence of immune complexes.
In giant cell arteritis and granulomatous vasculitis, cellular immune mechanisms are probably to blame and vessels are directly attacked. A reaction of antigen with sensitised lymphocytes results in lymphokine release - attracted mononuclear cells release lysosomal enzymes with resultant granuloma formation.
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