Intracranial Tumours Aetiologyincidence

AETIOLOGY (contd)

(b) Inactivation of expression of tumour suppressor genes.

(c) Over expression of genes controlling growth factor.

Clearly defined inherited factors play a minor role. Only 5% of patients have a family history of brain tumour and with the exception of tuberous sclerosis (related to the formation of subependymal astrocytomas) and neurofibromatosis (linked to an increased incidence of optic nerve glioma and meningioma) do not fall into an obvious autosomal recessive or dominant pattern.

Cranial irradiation: long term follow-up of patients undergoing whole head irradiation for tinea capitis shows an increased incidence of both benign and malignant tumours -astrocytoma, meningioma.

Immunosuppression: increased incidence of lymphoreticular tumours. INCIDENCE

The table below details the incidence of intracranial tumours examined by the Neuropathology Department, Institute of Neurological Sciences, Glasgow (population 2.7 million) over a 5 year period.

SUPRATENTORIAL

Adults

Children (< 15 years)

Anaplastic astrocytoma

(including glioblastoma) Meningioma Metastasis Astrocytoma Pituitary adenoma Craniopharyngioma Oligodendroglioma Colloid cyst Lymphoma Others

INFRATENTORIAL

Neuroma

Metastasis

Haemangioblastoma

Astrocytoma

Meningioma

Medulloblastoma

Dermoid/epidermoid

Ependymoma

suppression, the incidence of primary cerebral lymphoma has significantly

Graham and Doyle, 1981 Brain Biopsy)

suppression, the incidence of primary cerebral lymphoma has significantly

Others

Graham and Doyle, 1981 Brain Biopsy)

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