Inflammatory myopathy

Investigations

Diagnosis is supported by the following investigations:

Muscle enzymes

Creatine kinase (CK) is elevated. Released from necrotic muscle, it is an indicator of disease activity and severity Electromyography

Shows a typical myopathic pattern.

Circulating antibodies e.g. rheumatoid factor, antinuclear factor. Present in 40%.

Erythrocyte sedimentation rate (ESR) Elevated in most patients.

Muscle biopsy shows necrosis of muscle fibres with inflammatory cells - lymphocytes, plasma cells, leucocytes.

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