Treatment of recurrent GABHS pharyngitis

A. When patient compliance is an issue, an injection of penicillin G benzathine may be appropriate. When patient compliance is not an issue, therapy should be changed to a broader spectrum agent.

1. Cephalexin (Keflex) 250-500 mg tid x 5 days [250, 500 mg]

2. Cefadroxil (Duricef) 500 mg bid x 5 days [500 mg]

3. Loracarbef (Lorabid) 200-400 mg bid x 5 days [200, 400 mg]

4. Cefixime (Suprax) 400 mg qd x 5 days [200, 400 mg]

6. Cefuroxime axetil (Ceftin) 250-500 mg bid x 5 days [125, 250, 500 mg]

B. Amoxicillin/clavulanate (Augmentin) has demonstrated superior results in comparison with penicillin; 250-500 mg tid or 875 mg bid [250,500,875 mg].

C. Sulfonamides, trimethoprim, and the tetracyclines are not effective for the treatment of GABHS pharyngitis.

References: See page 195.

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