Troglitazone Rezulin

a. This agent is associated with weight gain and hypoglycemia. Starting dose is 200 mg once per day, which may be slowly increased to up to 600 mg once per day. Troglitazone should be administered with a meal and is often taken with breakfast. Metformin is more potent and usually associated with less serious side effects; therefore, troglitazone is a second-line agent.

b. Idiosyncratic hepatocellular injury and liver failure associated with mortality has been reported. Liver function testing (AST, alkaline phosphatase, LDH, bilirubin) is recommended every 2 weeks for 6 months after starting the medication and periodically thereafter.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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