Medroxyprogesterone acetate injections

A. Depot medroxyprogesterone acetate (Depo-Provera) is an injectable progestin. A 150-mg dose provides 12 weeks of contraception. However, an effective level of contraception is maintained for 14 weeks after an injec-tion.After discontinuation of the injections, resumption of ovulation requires nine months.

B. Every 12 weeks, the medication is given IM. An injection should be administered within five days after the onset of menses or after proof of a negative pregnancy test. Medroxyprogesterone may be administered immediately after childbirth.

C. Medroxyprogesterone injections are a good choice for patients, such as adolescents, who have difficulty remembering to take their oral contraceptive or who have a tendency to use other methods inconsistently. Medroxyprogesterone may also be a useful choice for women who have contraindications to estrogen. This method should not be used for women who desire a rapid return to fertility after discontinuing contraception.

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