Bisphosphonatesalendronate Fosamax

1. Alendronate is an oral bisphosphonate approved for the treatment and prevention of osteoporosis. Alendronate exerts its effect on bone by inhibiting osteoclasts.

2. The dose for prevention of osteoporosis is 5 mg per day. This dose results in significant increases in densities of 2-3.5%, similar to those observed in ERT. The dose for treatment of osteoporosis is 10 mg per day. Alendronate provides an approximate 50% reduction in fracture risk at both skeletal sites.

3. Patients should take the pill in the morning with 2-3 glasses of water, at least 30 minutes before any food or beverages. No other medication should be taken at the same time, particularly calcium preparations. Patients should not lie down after taking alendronate to avoid gastroesophageal reflux. Contraindicated include severe renal insufficiency and hypocalcemia.

References: See page 195.

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