Bile acidbinding resins

1. The anion exchange resins cholestyramine (Questran) and colestipol (Colestid) bind cholesterol-containing bile acids in the intestines. These agents decrease LDL cholesterol levels by up to 20 percent. They may be a good choice in patients with hepatic disease because they do not affect hepatic metabolism. They are also a good choice in very young patients and women of childbearing age.

2. Bile acid-binding resins may cause an increase in triglyceride levels. Side effects include constipation, abdominal discomfort, flatulence, nausea, bloating and heartburn.

3. Bile acid sequestrants can bind with warfarin, digitalis, thyroxine, thiazides, furosemide, tetracycline, penicillin G, phenobarbital, iron, propranolol, acetaminophen, nonsteroidal anti-inflammatory agents, oral phosphate, and hydrocortisone.

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