Disulfiram Antabuse

1. Disulfiram is an aversive agent. The dosage of is 250 mg per day. Disulfiram inhibits acetaldehyde dehydrogenase. An accumulation of acetaldehyde produces an unpleasant reaction when alcohol is consumed that is similar to a severe hangover. It is potentially lethal, although only a small number of fatalities have been reported. The reaction is characterized by headache, diaphoresis, tachycardia, nausea and vomiting, cardiovascular collapse, delirium, seizures and, occasionally, death.

2. Before using disulfiram, patients must have a blood alcohol level of zero and must be able to comprehend the risks and benefits of treatment.

B. Methadone maintenance is a form of pharmacologic management of opiate addiction performed in programs that are in compliance with federal regulations.

C. Naltrexone (ReVia) is an opioid antagonist which inhibits the effect of opiate agonists. Naltrexone is effective in decreasing relapse and the subjective craving for alcohol.

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