The Initial Stage of Periacinar Collagenization

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Our electron-microscope investigation revealed that myofibroblasts play an important role at the initial stage of periacinar collagenization [10]. Additionally, the transport blockage of proteins, which was reflected by the leakage of the

Fig. 9. Transportation of secretory products in the acinar cell. In normal cells, secretory products are condensed and modified in the Golgi complex (Golgi) and transform to small lysosomes and zymogen granules. Normal zymogen granules (nZG) are released by exocytosis into the lumen. In degenerative cells, the electron density of zymogen granules (dZG) is reduced, dilatation and vesiculation of the endoplasmic reticulum containing the amorphous and medium electron dense contents is often observed, and the numbers of lysosomes and lipid droplets (Lp) are increased. Primary lysosomes (Ly1) are fused resulting in secondary lysosomes (Ly2). The lipofuscin (Lpf)-like structure is derived from primary lysosomes and lipid droplets. Degenerative zymogen granules, secondary lysosomes and lipofuscins are extruded from the lateral and basal membranes. Nc = Nucleus. From [10] with permission.

Fig. 9. Transportation of secretory products in the acinar cell. In normal cells, secretory products are condensed and modified in the Golgi complex (Golgi) and transform to small lysosomes and zymogen granules. Normal zymogen granules (nZG) are released by exocytosis into the lumen. In degenerative cells, the electron density of zymogen granules (dZG) is reduced, dilatation and vesiculation of the endoplasmic reticulum containing the amorphous and medium electron dense contents is often observed, and the numbers of lysosomes and lipid droplets (Lp) are increased. Primary lysosomes (Ly1) are fused resulting in secondary lysosomes (Ly2). The lipofuscin (Lpf)-like structure is derived from primary lysosomes and lipid droplets. Degenerative zymogen granules, secondary lysosomes and lipofuscins are extruded from the lateral and basal membranes. Nc = Nucleus. From [10] with permission.

contents of zymogen granules and the rough endoplasmic reticulum to the cytoplasm and around acinar cells, is preceded by alcohol intake, and may contribute to the severe damage to acinar cells and the development of periacinar collageniza-tion. Further studies on the myofibroblasts around the acini and changes in acinar cells, especially the abnormalities in zymogen granules and GERL, will be useful for understanding periacinar collagenization followed by intralobular sclerosis. In another study, we demonstrated prolyl hydroxylase immunohistochemically in acinar cells [41]. Intracytoplasmic filaments up to 7-8 nm in diameter have also been investigated in degenerative acinar cells. The filaments were found in close proximity to the degenerative zymogen granules and lysosomes, and were confirmed to be caused by alcohol-enhanced metabolic injury to the acinar cells [32, 42]. Although it is known that several types of filaments or fibrils have also been found in the acinar cells during the degenerative process in chronic alcoholics, we cannot confirm at present whether or not the intracytoplasmic filaments in the acinar cells are strongly related to periacinar fibrosis. In the future, the relationship between the intracytoplasmic filaments and each organelle in the acinar cells will be elucidated. The mechanism of periacinar collagenization will be more interesting when it is confirmed that the acinar cells themselves participate in collagenization. The distribution of myofibroblasts in the periacinar and perilobular areas might provide a valuable clue to resolve in the near future the mechanisms of the three different types of pancreatic fibrosis in terms of pathogenesis.

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Beat The Battle With The Bottle

Beat The Battle With The Bottle

Alcoholism is something that can't be formed in easy terms. Alcoholism as a whole refers to the circumstance whereby there's an obsession in man to keep ingesting beverages with alcohol content which is injurious to health. The circumstance of alcoholism doesn't let the person addicted have any command over ingestion despite being cognizant of the damaging consequences ensuing from it.

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