1 Sommers SC, Murphy SA, Warren S: Pancreatic duct hyperplasia and cancer. Gastroenterology 1954;27:629-640.

2 Zalatnai A: Pancreatic cancer - a continuing challenge in oncology. Pathol Oncol Res 2003;9:252-263.

3 Cubilla AL, Fitzgerald PJ: Morphological lesions associated with human primary invasive nonen-docrine pancreas cancer. Cancer Res 1976;36:2690-2698.

4 Kozuka S, Sassa R, Taki T, et al: Relation of pancreatic duct hyperplasia to carcinoma. Cancer 1979;43:1418-1428.

5 Tada M, Ohashi M, Shiratori Y, et al: Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 1996;110:227-231.

6 Suda K, Mogaki M, Oyama T: A comparison between hyperplasia of ductal epithelium and mucin producing tumor of the pancreas. Rinsho Byori 1991;39:1220-1224.

7 Klimstra DS, Longnecker DS: K-ras mutations in pancreatic ductal proliferative lesions. Am J Pathol 1994;145:1547-1548.

8 Ohhashi K, Murakami Y, Yakekoshi T: Four cases of 'mucinous producing' cancer of the pancreas on specific findings of the papilla of Vater. Prog Dig Endosc 1982;20:348-351.

9 Hruban RH, Takaori K, Klimstra DS, et al: An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 2004;28:977-987.

10 Hruban RH, Adsay NV Albores-Saavedra J, et al: Pancreatic intraepithelial neoplasia (PanIN): a New nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001;25:579-586.

11 Longnecker DS, Adler G, Hruban RH, Kloppel G: Intraductal papillary-mucinous neoplasms of the pancreas; in WHO Classification of Tumors of the Digestive System. 2000, pp 237-240.

12 Kim YS, Gum J Jr, Brockhausen I: Mucin glycoproteins in neoplasia. Glycoconj J 1996;13: 693-707.

13 Kim YS, Gum JR Jr, Crawley SC, et al: Mucin gene and antigen expression in biliopancreatic carcinogenesis. Ann Oncol 1999;10:S51-S55.

14 Itzkowitz S, Kjeldsen T, Friera A, et al: Expression of Tn, Sialyosyl Tn, and T antigens in human pancreas. Gastroenterology 1991;100:1691-1700.

15 Williams SJ, Wreschner DH, Tran M, et al: MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem 2001;276:18327-18336.

16 Hendrix H, Hewetson A, Mansharamani M, et al: Oviduct (MUC9) is expressed in rabbit endo-cervix. Endocrinology 2001;142:2151-2154.

17 Melnick M, Chen H, Zhou Y, et al: An alternatively spliced Muc 10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesis. Arch Oral Biol 2001;46:745-757.

18 Williams SJ, McGuckin MA, Gotley DC, et al: Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res 1999;59:4083-4089.

19 Adsay NV, Merati K, Andea A, et al: The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod Pathol 2002;15:1087-1095.

20 Nakamura A, Horinouchi M, Goto M, et al: New classification of pancreatic intraductal papillary-mucinous tumor by mucin expression: its relationship with potential for malignancy. J Pathol 2002;197:201-210.

21 Adsay NV, Merati K, Nassar H, et al: Pathogenesis of colloid (pure-mucinous) carcinoma of exocrine organs: coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas. Am J Surg Pathol 2003;27:571-578.

22 Luttges J, Schlehe B, Menke MA, et al: The K-ras mutation pattern in pancreatic ductal adenocar-cinoma usually is identical to that in associated normal, hyperplastic and metaplastic ductal epithelium. Cancer 1999;85:1703-1710.

23 Luttges J, Diederichs A, Menke MA, et al: Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53. Cancer 2000;88:2495-2504.

24 Kloppel G, Bommer G, Ruckert K, et al: Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis. Virchows Arch A Pathol Anat Histol 1980;387:221-233.

25 Matsubayashi H, Watanabe H, Nishikura K, et al: Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation. Cancer 1998;82:651-660.

26 Terhune PG, Phifer DM, Tosteson TD, et al: K-ras mutation in focal proliferative lesions of human pancreas. Cancer Epidemiol Biomarkers Prev 1998;7:515-521.

27 Lemoine NR, Jain S, Hughes CM, et al: Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 1992:102:230-236.

28 Terada T, Ohta T, Kitamura Y, et al: Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. Arch Pathol Lab Med 1998;122:42-46.

29 Abe K, Suda K, Arakawa A, et al: Different pattern of p16 and p53 protein expression in intraduc-tal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia. Pancreas; in print.

Keiko Abe, MD

Department of Human Pathology, Juntendo University School of Medicine 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 (Japan)

Tel. +81 3 5802 1037, Fax +81 3 3812 1056, E-Mail [email protected]

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