Halki Diabetes Remedy

Foods to avoid when you have Diabetes

Get Instant Access

1 Suda K, Takase M, Fukumura Y, et al: Histopathologic difference between chronic pancreatitis animal models and human chronic pancreatitis. Pancreas 2004;28:386-389.

2 Silverman M, Ilardi C, Bank S, et al: Effects of the cholecystokinin antagonist L-364,717 on experimental pancreatitis in mice. Gastroenterology 1989;96:186-192.

3 Wisner JR, Ozawa S, Renner IG: The effects of nafamostat mesilate (FUT-175) on caerulein-induced acute pancreatitis in the rat. Int J Pancreatol 1989;4:383-390.

4 Manabe T, Hirano T, Imanishi K, et al: Protective effect of nafamostat mesilate on cellular and lysosomal fragility of acinar cells in rat cerulean pancreatitis. Int J Pancreatol 1992;12:167-172.

5 Otsuki M, Tani S, Okabayashi Y, et al: Effect of a new cholecystokinin receptor antagonist CR1392 on caerulein-induced acute pancreatitis in rats. Pancreas 1989;4:237-243.

present in the intralobular and interlobular areas of fibrosis, which areas undergo resolution. The appearance of type I collagen around the ducts is thought to be the reason why ductal fibrosis in DBTC model rats is hard to resolve.

Rosato EF, Mullis WF, Rosato FE: Peritoneal lavage therapy in haemorrhagic pancreatitis. Surgery 1973;74:106-115.

Wisner JR Jr, Renner IG, Grendell JH, et al: Gabexate mesilate (FOY) protects against ceruletide-induced acute pancreatitis in the rat. Pancreas 1987;2:181-186.

Iwaki M, Ino Y, Motoyoshi A, et al: Pharmacological studies of FUT-175, nafamostat mesilate. V. Effects on the pancreatic enzymes and experimental pancreatitis in rats. Jpn J Pharmacol 1986;41:155-162.

Oruc N, Ozutemiz AO, Yukselen V et al: Infliximab: a new therapeutic agent in acute pancreatitis? Pancreas 2004;28:e1-e8.

Atten MJ, Verma A, Liu K: Antioxidants up-regulate PPAR and decrease fibrosis in chronic pancreatitis. Am J Gastroenterol 2003;98:A14.

Steinberg W, Tenner S: Acute pancreatitis. N Engl J Med 1994;330:1198-1210. Dominguez-Munoz JE, Carballo F, Garcia MJ, et al: Evaluation of the clinical usefulness of APCHE II and SAPS systems in the initial prognostic classification of acute pancreatitis: a multicenter study. Pancreas 1993;8:682-686.

Sarner M, Cotton PB: Classification of pancreatitis. Gut 1984;25:756-759.

George SH, Adelais TG: Etiology and pathogenesis of acute pancreatitis: current concepts. J Clin

Gastroenterol 2000;30:343-356.

Jalovaara P, Apaja M: Alcohol and acute pancreatitis: an experimental study in the rat. Scand J Gastroenterol 1978;13:703-709.

Ekstrom G, Ingelman-Sundberg M: Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450(P-450IIE1). Biochem Pharmacol 1989;38:1313-1319.

McCutcheon AD: A fresh approach to the pathogenesis of pancreatitis. Gut 1968;9:296-310. Layer P, Yamamoto H, Kalthoff L, et al: The different courses of early and late onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology 1994;107:1481-1487.

Trapnell JE, Duncan EH: Patterns of incidence in acute pancreatitis. Br Med J 1975 26;2:179-183. Goodhead B: Vascular factors in the pathogenesis of acute haemorrhagic pancreatitis. Am R Coll Surg Engl 1969;45:80-97.

Novis BH, Young GO, Bank S, Marks IN: Chronic pancreatitis and alpha-1-antitrypsin. Lancet 1975;2:748-749.

Rosa-e-Silva L, Oliveira RB, Troncon LE, et al: Autonomic nervous function in alcohol-related chronic pancreatitis. Pancreas 2000;20:361-366.

Mills JD, Sparks BB: A discussion of pancreatic necrosis (with case report). Can Med Assoc J 1932;27:381-385.

Lerch MM, Saluja AK, Runzi M, et al: Pancreatic duct obstruction triggers acute necrotizing pancreatitis in the opossum. Gastroenterology 1993;104:853-861.

Opie EL: The etiology of acute hemorrhagic pancreatitis. Bull Johns Hopkins Hospital 1901;12: 182-188.

Opie EL: The relation of cholelithiasis to disease of the pancreas and the fat necrosis. Am J Med Sci 1901;121:27-43.

Testoni PA: Aetiologies of recurrent acute pancreatitis: acute or chronic relapsing disease? JOP 2001;2:357-367.

Stevens T, Conwell DC, Zuccaro G: Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developments. Am J Gastroenterol 2004;99:2256-2270. Dreiling A, Richman A, Fradkin N: The role of alcohol in the etiology of pancreatitis: a study of the effect of intravenous ethyl alcohol on the external secretion of the pancreas. Gastroenterology 1952;20:636-646.

Sari R, Palvolgyi A, Rakonczay Z, et al: Ethanol inhibits the motility of rabbit sphincter Oddi in vitro. World J Gastroenterol 2004;10:3470-3474.

Wilson JS, Korsten MA, Pirola RC: Alcohol-induced pancreatic injury (part I). Unexplained features and ductular theories of pathogenesis. Int J Pancreatol 1989;4:109-125. Sarles H: Chronic calcifying pancreatitis: chronic alcoholic pancreatitis. Gastroenterology 1974;66:604-616.

Noel-Jorand MC, Colomb E, Astier JP, et al: Pancreatic basal secretion in alcoholic-fed and normal dogs. Dig Dis Sci 1981;26:783-789.

Payan H, Sarles H, Demirdijan M, et al: Study of histological features of chronic pancreatitis by correspondence analysis: Identification of chronic calcifying pancreatitis as an entity. Rev Eur Etud Clin Biol 1972;17:663-670.

Suda K, Miyano T, Suzuki F, et al: Clinicopathologic and experimental studies on cases of abnormal pancreatico-choledocho-ductal junction. Acta Pathol Jpn 1987;37:1549-1562. Aranha GV, Prinz RA, Freeark RJ, et al: The spectrum of biliary tract obstruction from chronic pancreatitis. Arch Surg 1984;119:595-600.

Neoptolemos JP: The theory of 'persisting' common bile duct stones in severe gallstone pancreatitis. Ann R Coll Surg Engl 1989;71:326-331.

Klöppel G, Maillet B: The morphological basis for evolution of acute pancreatitis into chronic pancreatitis. Virchows Arch A 1992;420:1-4.

Whitcomb DC: Hereditary pancreatitis: new insights into acute and chronic pancreatitis. Gut 1999;45:317-22.

Ammann RW, Muelhaupt B: Progression of alcoholic acute to chronic pancreatitis. Gut 1994;35:552-556.

Singer MV, Gyr K, Sarles H: Revised classification of pancreatitis: report of the second international symposium on the classification of pancreatitis in Marseille, France, March 28-30, 1984. Gastroenterology 1985;89:683-685.

Sarner M: Pancreatitis definitions and classification; in Go VLD (ed): The Exocrine Pancreas: Biology, Pathobiology and Disease. New York, Raven Press, 1986, pp 459-464. Suda K, Mogaki M, Oyama T, et al: Histopathologic and immunohistochemical studies on alcoholic pancreatitis and chronic obstructive pancreatitis: Special emphasis on ductal obstruction and genesis of pancreatitis. Am J Gastroenterol 1990;85:271-276.

Suda K, Takase M, Takei K, et al: Histopathologic and immunohistochemical studies on the mechanism of interlobular fibrosis of the pancreas. Arch Pathol Lab Med 2000;124:1302-1305. Forsmark CE: Chronic pancreatitis; in Feldman M, Friedman LS, Sleisenger MH (eds): Sleisenger and Fordtran's Gastrointestinal and Liver Disease, ed 7. Philadelphia, Saunders, 2002, pp 944-969. Sidhu SS, Tandon RK: The pathogenesis of chronic pancreatitis. Postgrad Med 1995;71:67-70. Suda K, Miyano T: Bile pancreatitis. Arch Pathol Lab Med 1985;109:433-436. Braganza JM, Klass HJ, Bell M, et al: Evidence of altered copper metabolism in patients with chronic pancreatitis. Clin Sci 1981;60:303-310.

Homma T, Harada H, Koizumi M: Diagnostic criteria for chronic pancreatitis by the Japan Pancreas Society. Pancreas 1997;15:14-15.

Suda K, Takase M, Takei K, et al: Histopathologic study of coexistent pathologic states in pancreatic fibrosis in patients with chronic alcohol abuse: two distinct pathologic fibrosis entities with different mechanisms. Pancreas 1996;12:369-372.

Etemad B, Whitcomb DC: Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology 2001;120:682-707.

Stolte M: Chronic pancreatitis; in Buchler V, Hubner K (eds): The Pancreas in Connection with Epigastric Unit. Stuttgart, Gustav Fischer Verlag, 1988, pp 110-121.

Klöppel G: Pathology of chronic pancreatitis and pancreatic pain. Acta Chir Scand 1990;156: 261-265.

Seki K, Kawano K, Kamino K: Expression of histocompatibility antigen HLA-DR on the epithelial cells of the pancreatic duct and thyroid follicle. An autopsy case. Acta Pathol Jpn 1990;40:442-447. Okazaki K, Uchida K, Chiba T: Recent concept of autoimmune-related pancreatitis. J Gastroenterol 2001;36:293-302.

Uchida K, Okazaki K, Konishi Y, et al: Clinical analysis of autoimmune-related pancreatitis. Am J Gastroenterol 2000;95:2788-2794.

Ohara M, Okazaki K, Hajiro K, et al: Multiple pancreatic masses associated with autoimmunity. Am J Gastroenterol 1998;93:99-102.

Suda K, Takase M, Fukumura Y, et al: Histopathologic characteristics of autoimmune pancreatitis based on comparison with chronic pancreatitis. Pancreas 2005;30:355-358.

Klöppel G, Maillet B: Chronic pancreatitis: evolution of the disease. Hepatogastroenterol 1991;38:408-412.

Comfort MW, Gaubill EE, Baggenstos AM: Chronic pancreatitis, an analysis of 29 cases without associated disease of the biliary or gastro-intestinal tract. Gastroenterology 1946;6:239-285.

Schmitz-Moormann P: Comparative radiological and morphological study of the human pancreas.

IV Acute necrotizing pancreatitis in man. Pathol Res Pract 1981;171:325-335.

Xie MJ, Motoo Y, Su SB, et al: Expression of tumor necrosis factor-alpha, interleukin-6, and inter-

feron-gamma in spontaneous chronic pancreatitis in the WBN/Kob rat. Pancreas 2001;22:


Tsuchitani M, Saegusa T, Narama I, et al: A new diabetic strain of rat (WBN/Kob). Lab Anim 1985;19:200-207.

Ohashi K, Kim JH, Hara H, et al: WBN/Kob rats. A new spontaneously occurring model of chronic pancreatitis. Int J Pancreatol 1990;6:231-247.

Tsuchitani M, Wako Y, Yamagishi Y, et al: Endocrine cell populations in the pancreas of diabetic WBN/Kob rats. J Vet Med Sci 1992;54:429-434.

Kakinuma C, Suda K, Shibutani Y. Histopathological and biochemical studies on pancreatic fibro-sis in WBN/Kob rats. Virchows Arch 1999;434:83-89.

Hashimoto T, Yamada T, Yokoi T, et al: Apoptosis of acinar cells is involved in chronic pancreatitis in WBN/Kob rats: role of glucocorticoids. Pancreas 2000;21:296-304.

Su SB, Motoo Y, Xie MJ, et al: Apoptosis in the rat spontaneous chronic pancreatitis: role of the Fas and Fas ligand system. Dig Dis Sci 2001;46:116-175.

Erspamer V, Bertaccini G, De Caro G, et al: Pharmacological action of caerulein. Experimentia 1967;23:702-703.

Bertaccini G, Braibanti T, Uva F: Cholecystokinetic activity of the new polypeptide caerulein in man. Gastroenterology 1969;56:862-867.

Bertaccini G, De Caro G, Endean R, et al: The action of caerulein on pancreatic secretion of the dog and biliary secretion in the dog and rat. Br J Pharmacol 1969;37:185-197. Watanabe O, Baccino FM, Steer ML, et al: Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol 1984;246:G457-G467.

Elsasser HP, Haake T, Grimmig M, et al: Repetitive cerulein-induced pancreatitis and pancreatic fibrosis in the rat. Pancreas 1992;7:385-390.

Adler G, Hahn C, Kern HF, et al: Cerulein-induced pancreatitis in rats: increased lysosomal enzyme activity and autophagocytosis. Digestion 1985;32:10-18.

Adler G, Rohr G, Kerm HF: Alteration of membrane fusion as a cause of acute pancreatitis in the rat. Dig Dis Sci 1982;27:993-1002.

Sarles H, Sahel J: Pathology of chronic calcifying pancreatitis. Am J Gastroenterol 1976;66: 117-139.

Jin CX, Naruse S, Kitagawa M, et al: Pancreatic stone protein of pancreatic calculi in chronic calcified pancreatitis in man. JOP 2002;3:54-61.

Barthet M, Valantin V Spinosa S, et al: Clinical course and morphological features of chronic calcifying pancreatitis associated with pancreas divisum. Eur J Gastroenterol Hepatol 1995;7:993-998. Fent K: Ecotoxicology of organotin compounds. Crit Rev Toxicol 1996;26:1-117. Merkord J, Jonas L, Weber H, et al: Acute interstitial pancreatitis in rats induced by dibutyltin dichloride (DBTC): pathogenesis and natural course of lesions. Pancreas 1997;15:392-401. Sparmann G, Merkord J, Jaschke A, et al: Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology 1997;112:1664-1672.

Merkord J, Weber H, Sparmann G, et al: The course of pancreatic fibrosis induced by dibutyltin dichloride (DBTC). Ann N Y Acad Sci 1999;880:231-237.

Stokinger HE: The metals; in Clayton GD, Clayton FE (eds): Patty's Industrial Hygiene and Toxicology, ed 3. New York, John Wiley & Sons, 1981-1982, vol 2A, pp 1953-1955. Boyer IJ: Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals. Toxicology 1989;55:253-298.

Richards C, Fitzgerald PJ, Carol B, et al: Segmental division of the rat pancreas for experimental procedures. Lab Invest 1964;13:1303-1321.

Block MA, Vakin KG, Baggenstoss AH: Experimental studies concerning factors in the pathogenesis of acute pancreatitis. Surg Gynecol Obstet 1954;99:83-90.

Christophersen WM, Floyd CN: Experimental chronic pancreatitis. AMA Arch Surg 1956;73: 701-709.

Hermann RE, Davis JH: The role of incomplete pancreatic duct obstruction in the etiology of pancreatitis. Surgery 1960;48:318-329.

Fitzgerald PJ: Autoradiographic labeling of pancreatic acinar cells with thymidine-H3 during degeneration and regeneration. Can Med Assoc J 1963;88:480-482.

Zelander T, Ekholm R, Edlund Y: The ultrastructure of the rat exocrine pancreas after experimentally occluded outflow. J Ultrastructure Res 1964;10:89-102.

Ohshio G, Saluja A, Steer ML: Effects of short-term pancreatic duct obstruction in rats. Gastroenterology 1991;100:196-202.

Siech M, Heinrich P, Letko G: Development of acute pancreatitis in rats after single ethanol administration and induction of a pancreatic juice edema. Int J Pancreatol 1991;8:169-175. Takase M, Suda K: Histopathological study on mechanism and background of tumor-forming pancreatitis. Pathol Int 2001;51:349-354.

Kulling D, Tresch S, Renner E: Triad of sclerosing cholangitis, chronic pancreatitis, and Sjogren's syndrome: case report and review. Gastroenterol Endosc 2003;57:118-120. Uchida K, Okazaki K, Chiba T: An animal model of autoimmune pancreatitis using neonatally thymectomized mice. Gastroenterology 1998;112:A505.

Miyawaki S, Nakamura Y, Suzuka H, et al: A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol 1994;24:429-434. Tsubata R, Tsubata T, Hiai H, et al: Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjogren's syndrome. Eur J Immunol 1996;26:2742-2748.

Tsuneyama K, Kono N, Hoso M, et al: Aly/aly mice: a unique model of biliary disease. Hepatology 1998;27:1499-1507.

Ishida K, Mizuno A, Sano T, et al: Plasma glucagon responses to insulin-induced hypoglycemia and arginine in spontaneous non-insulin-dependent diabetes mellitus (NIDDM) rats, Otsuka Long Evans Tokushima Fatty (OLETF) strain. Acta Endocrinol (Copenh) 1993;129:585-593. Jia D, Taguchi M, Otsuki M: Preventive and therapeutic effects of the protease inhibitor camostata on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats. Pancreas 2005;30:54-61. Sato T, Niikawa J, Imamura T, et al: Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression. J Gastroenterol 2003;38; 672-680.

Kawano K, Hirashima T, Mori S, et al: OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain. Diabetes Res Clin Pract 1994;24 (suppl):S317-S320.

Yoshikawa H, Kihara Y, Taguchi M, et al: Role of TGF-beta 1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol 2002;282:G549-G558.

Dahl LK, Heine M, Tassinari T: Effects of chronic excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension. J Exp Med 1962;115: 1173-1180.

Alvarez-Guerra M, Garay RP: Renal Na-K-Cl cotransporter NKCC2 in Dahl salt-sensitive rats. J Hypertens 2002;20:605-606.

Tamura K, Chiba E, Yokoyama N, et al: Renin-angiotensin system and fibronectin gene expression in Dahl Iwai salt-sensitive and salt-resistant rats. J Hypertens 1999;17:81-89. Onizuka S, Ito M, Sekine I, et al: Spontaneous pancreatitis in spontaneously hypertensive rats. Pancreas 1994;9:54-61.

Fitzgerald PJ, Alvizouri M: Rapid restitution of the rat pancreas following acinar cell necrosis subsequent to ethionine. Nature 1952;170:929-930.

Lyman RL, Thenen S, Tucker R: Effect on the rat pancreas of feeding DL-ethionine, with or without adenine triphosphate for 1 to 10 days. Can J Biochem 1966;44:1345-1355.

Goebell H: The effect of ethionine on the energy-producing metabolism in the rat pancreas. II. Alterations of tissue levels of adenine nucleotides, pyridine nucleotides, and glycolytic metabolites. Horm Metab Res 1974;6:44-49.

Koike H, Steer ML, Meldolesi J: Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis. Am J Physiol 1982;242: G297-G307.

Rodriguez AI, de Dios I, Garcia-Montero AC, et al: Acute necrotizing pancreatitis induced by a CDE diet in the rat: a morphologic and functional study. J Lab Clin Med 1994;123:693-700. Lombardi B, Estes LW, Longnecker DW: Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by dl-ethionine fed with a choline-deficient diet. Am J Pathol 1975;79:465-480.

Virji MA, Rao KN: Acute hemorrhagic pancreatitis in mice: a study of glucoregulatory hormones and glucose metabolism. Am J Pathol 1985;118:162-167.

Niederau C, Grendell H: Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified component. J Clin Invest 1988;81:229-236.

Watanabe A, Miyazaki M, Takeka K: Prompt elevation of rat serum alpha-fetoprotein by acute liver injury following a single injection of ethionine. Int J Cancer 1976;17:518-524.

Flaks B, Nicoll JW: Modification of toxic liver injury in the rat II. Protective effect of cyclohex-

imide on ethionine-induced damage and autoprotective effects of high doses of ethionine, 3'-

methyl-4-dimethylaminoazobenzene, and 2-acetylaminofluorene. Toxicol Appl Pharmacol 1975;32:


Alix JH: Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine. Microbiol Rev 1982;46:281-295.

Takacs T, Czako L, Morschl E, et al: The role of nitric oxide in edema formation in L-arginine-induced acute pancreatitis. Pancreas 2002;25:277-282.

Kihara Y, Tashiro M, Nakamura H, et al: Role of TGF-beta 1, extracellular matrix, and matrix met-alloprotease in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats. Pancreas 2001;23:288-295.

Hegyi P, Rakonczay Z, Sari R, et al: L-arginine-induced experimental pancreatitis. World J Gastroenterol 2004;10:2003-2009.

Takacs T, Czako L, Jarmay K, et al: Cytokine level changes in L-arginine-induced acute pancreatitis in rat. Acta Physiol Hung 1996;84:147-156.

Hegyi P, Takacs T, Jarmay K, et al: Spontaneous and cholecystokinin-octapeptide-promoted regeneration of the pancreas following L-arginine-induced pancreatitis in rat. Int J Pancreatol 1997;22:193-200.

Tani S, Itoh H, Okabayashi Y, et al: New model of acute necrotizing pancreatitis induced by excessive doses of arginine in rats. Dig Dis Sci 1990;35:367-374.

Mizunuma T, Kawamura S, Kishino Y: Effects of injecting excess arginine on rat pancreas. J Nutr 1984;114:67-71.

Gukovskaya AS, Perkins P, Zaninovic V, et al: Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 1996;110:875-884.

Kaiser AM, Saluja AK, Sengupta A, et al: Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;269:C1295-C1304.

Scoggins CR, Meszoely IM, Wada M, et al: p53-deficient acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas. Am J Physiol Gastrointest Liver Physiol


He ZJ, Podkletnova I, Alho H, et al: Apoptosis in acute pancreatitis. Ann Chir Gynaecol 2000;89:65-67.

Bhatia M: Apoptosis versus necrosis in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 2004;286:G189-G196.

Bhatia M: Apoptosis of pancreatic acinar cells in acute pancreatitis: is good or bad? J Cell Mol Med 2004;8:402-409.

Calvo EL, Mallo GV, Fiedler F, et al: Clusterin overexpression in rat pancreas during the acute phase of pancreatitis and pancreatic development. Eur J Biochem 1998;254:282-289.

Takeyama Y, Takas K, Ueda T, et al: Peripheral lymphocyte reduction in severe acute pancreatitis caused by apoptotic cell death. J Gastrointest Surg 2000;4:379-386.

Gujral JS, Knight TR, Farhood A, et al: Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci 2002;67:322-328.

Kanduc D, Mittelman A, Serpico R, et al: Cell death: apoptosis versus necrosis (review). Int J Oncol 2002;21:165-170.

Levin S, Bucci TJ, Cohen SM, et al: The nomenclature of cell death: recommendations of ad hoc Committee of the Society of Toxicologic Pathologists. Toxicol Pathol 1999;27:484-490. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501. Rao JK, Letada P, Haverstick DM, et al: Modifications to the in situ TUNEL method for detection of apoptosis in paraffin-embedded tissue sections. Ann Clin Lab Sci 1998;28:131-137. Kakinuma C, Takagaki K, Yatomi T, et al: Acute toxicity of an anti-Fas antibody in mice. Toxicol Pathol 1999;27:412-420.

Zhang M, Liu F, Zou P, et al: Inhibition of mouse hepatocyte apoptosis via anti-Fas ribozyme. World J Gastroenterol 2004;10:2567-2570.

Kimura K, Shimosegawa T, Abe R, et al: Low doses of lipopolysaccharide upregulate acinar cell apoptosis in cerulein pancreatitis. Pancreas 1998;17:20-26.

Ding SP, Li JC, Jin C: A mouse model of severe acute pancreatitis induced with caerulein and lipopolysaccharide. World J Gastroenterol 2003;9:584-589.

Qui-Feng H, Takeda K, Mikami Y, et al: Effects of second attack by LPS on hepatic oxidative stress reactions in acute pancreatitis. Pancreatology 2002;2:217-361.

Fortunato F, Deng X, Gates LK, et al: Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis? Am J Physiol Gastrointest Liver Physiol 2006;290: G232-G241.

Mathison JC, Wolfson E, Ulevitch RJ: Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest 1988;81:1925-1937.

Schimke J, Mathison J, Morgiewicz J, et al: Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin. Proc Natl Acad Sci USA 1998;95:13875-13880. Yokota T, Denham W, Murayama K, et al: Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis. J Surg Res 2002;104:106-111.

Ohnishi N, Miyata T, Ohnishi H, et al: Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut 2003;52:1487-1493. Phillips PA, McCarroll JA, Park S, et al: Rat pancreatic stellate cells secrete matrix metallopro-teinases: implications for extracellular matrix turnover. Gut 2003;52:275-282. Gress TM, Muller-Pillasch F, Lerch MM, et al: Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis. Gastroenterol 1994;32:21-25.

Henkel W, Glanville RW: Covalent crosslinking between molecules of type I and type III collagen. The involvement of the N-terminal, nonhelical regions of the alpha 1 (I) and alpha 1 (III) chains in the formation of intermolecular crosslinks. Eur J Biochem 1982;122:205-213. Keene DR, Sakai LY, Bachinger HP, et al: Type III collagen can be present on banded collagen fibrils regardless of fibril diameter. J Cell Biol 1987;105:2393-2402.

Kennedy RH, Bockman DE, Uscanga L, et al: Pancreatic extracellular matrix alterations in chronic pancreatitis. Pancreas 1987;2:61-72.

Whitcomb DC, Preston RA, Aston CE, et al: A gene for hereditary pancreatitis maps to chromosome 7q35. Gastroenterology 1996;110:1975-1980.

Whitecomb DC: Hereditary pancreatitis: a model for understanding the genetic basis of acute and chronic pancreatitis. Pancreatology 2001;1:565-570.

Van Laethem JL, Devier J, Resibois A, et al: Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis. Gastroenterology 1995;108:1873-1881. Vogelmann R, Ruf D, Wagner M, et al: Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta 1 transgenic mouse model. Am J Physiol 2001;280:G164-G172.

158 Whitcomb DC, Gorry MC, Preston RA, et al: Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141-145.

159 Witt H, Luck W, Becker M, et al: Mutation in the SPINK 1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis. JAMA 2001;265:2716-2717.

160 Pezzilli R, Morselli-Labate AM, Mantovani V, et al: Mutations of the CFTR gene in pancreatic disease. Pancreas 2003;27:332-336.

161 Teich N, Mossner J, Keim V: Screening for mutations of the cationic trypsinogen genes: are they of relevance in chronic alcoholic pancreatitis ? Gut 1999;44:413-416.

162 Haber P, Keogh G, Apte M, et al: Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 1999;155:1087-1095.

163 Apte MV Phillips PA, Fahmy RG, et al: Does alcohol directly stimulate pancreatitis fibrogenesis? Studies with rat pancreatic satellite cells. Gastroenterology 2000;118:780-794.

164 Ruteshouser EC, de Crombrugghe B: Characterization of two distinct positive cis-acting elements in the mouse alpha 1(111) collagen promoter. J Biol Chem 1989;64:3740-3744.

165 Inagaki Y, Truter S, Ramirez F: Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 1994;269:14828-14834.

166 Schmid-Kotsaa A, Gross HJ, Menke A, et al: Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type 1 and C-fibronectin in cultured pancreatic satellite cells. Am J Pathol 1999;155:1749-1758.

167 Casini A, Galli A, Pignalosa P, et al: Collagen type I synthesized by pancreatic periacinar satellite cells (PSP) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis. J Pathol 2000;192:81-89.

Chihaya Kakinuma, PhD

Department of Human Pathology, Juntendo University School of Medicine 2-1-1, Hongo, Bunkyo-ku Tokyo 113-8421 (Japan)

Tel. +81 3 5802 1037, Fax +81 3 3812 1056, E-Mail [email protected]

Suda K (ed): Pancreas - Pathological Practice and Research. Basel, Karger, 2007, pp 135-145

Was this article helpful?

0 0
Delicious Diabetic Recipes

Delicious Diabetic Recipes

This brilliant guide will teach you how to cook all those delicious recipes for people who have diabetes.

Get My Free Ebook

Post a comment