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2 Gocke CD, Dabbs DJ, Benko FA, Silverman JF: KRAS oncogene mutations suggest a common histogenetic origin for pleomorphic giant cell tumor of the pancreas, osteoclastoma of the pancreas, and pancreatic duct adenocarcinoma. Hum Pathol 1997;28:80-83.

3 Hoorens A, Prenzel K, Lemoine NR, Kloppel G: Undifferentiated carcinoma of the pancreas: Analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin. J Pathol 1998;185:53-60.

4 Deckard-Janatpour K, Kragel S, Teplitz RL, Min BH, Gumerlock PH, Frey CF, Ruebner BH: Tumors of the pancreas with osteoclast-like and pleomorphic giant cells: an immunohistochemical and ploidy study. Arch Pathol Lab Med 1998;122:266-272.

5 Suda K, Takase M, Oyama T, Mitsui T, Horike S: An osteoclast-like giant cell tumor pattern in a mucinous cystadenocarcinoma of the pancreas with lymph node metastasis in a patient surviving over 10 years. Virchows Arch 2001;438:519-520.

usual pancre-various histo-cells, ranging

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10 Miyake T, Suda K, Yamamura A: Pathological and immunohistochemical analysis of giant cells of pancreas (in Japanese). Jpn J Gastroenterol 1997;94:649-657.

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Tomoo Miyake Department of Surgery Tanashi Hospital

3-6-1 Midori-cho Nishitokyo-shi, Tokyo 188-0002 (Japan) Tel. +81 42 461 2682, E-Mail [email protected]

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