Prognosis

The presence or absence of intraductal spread of carcinoma is correlated with the grade of tumor differentiation (p = 0.015), but not with tumor stage

Months

Fig. 9. Kaplan-Meier survival curves in patients with IDC according to the presence (n = 31) or absence (n = 16) of intraductal spread.

Months

Fig. 9. Kaplan-Meier survival curves in patients with IDC according to the presence (n = 31) or absence (n = 16) of intraductal spread.

(p = 0.28) [14]. IDC with intraductal components tends to be associated with longer survival compared with IDC without an intraductal component. Thirty-one patients whose IDAP had intraductal components had a median survival of 12 months, compared to 8 months for 16 patients whose IDC did not have intraductal spread (p = 0.09) (fig. 9). Fukushima et al. showed that IDC with intraductal components was associated with long-term survival of patients (p = 0.002) [29]. It is known that histologic grade is essentially a prognostic factor [27]. The longer survival of patients with intraductal spread might reflect the fact that this group has a higher fraction of well-differentiated tumors.

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