Pathologic Findings of Pancreas in Sjogrens Syndrome

In 1965, Bloch et al. studied clinical and pathological fingings in 62 cases with SS [9]. In their study, abnormalities in the pancreas at necropsy were acute atrophy and disorganization of the pancreatic parenchyma, areas of acinal tissue replaced by vascular connective tissue and heavy cellular infiltration, and oncocytic changes in several acini [9]. Later, in 1981, Nakamura et al. studied pathological findings in 6 autopsies with SS, and reported that acinal atrophy and oncocytic changes of acinal and duct cells were common findings, found in 4 of 6 cases [10]. Intestinal lymphocytic infiltrates were found in 3 cases, and others were interstitial fibrosis, acinal ectasis with eosinophilic plug, and parenchymal fatty infiltration [10].

Recently, autoimmune pancreatitis was proposed as a new clinical entity [11]. The disease was designated as idiopathic chronic pancreatitis with a possible etiologic factor of autoimmunity. SS overlapped with autoimmune pancreatitis in about a quarter of the cases [12]. However, in most cases with SS, no inflammation or mild inflammatory reaction is seen in the pancreas, and the case reports of pancreatitis are few. This leads to the conclusion that SS usually does not cause autoimmune pancreatitis by itself.

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