Immunohistochemical and Ultrastructural Findings

SCTs are positive for cytokeratins, detected by AE1/AE3 or CAM5.2, epithelial membrane antigen, CA19-9, neuron-specific enolase and a-inhibin [1, 9]. SCTs express cytokeratins 7, 8, 18, 19, MUC1, and MUC6, which characterize pancreatic duct cells including the centroacinar cells (fig. 10) [9, 33]. Cytokeratin 20, CEA, estrogen and progesterone receptors, and endocrine markers are unexpressed.

Ultrastructural studies have shown prominent apical microvilli, well-formed desmosomes, and contractile filaments [6, 8, 10]. Glycogen is abundant within cyst-lining cells. Tumor cells are relatively organelle-poor. These features are comparable to those of normal centroacinar cells [10].

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