Histological Grading Benign BorderlineCarcinoma

According to the WHO classification [10], pancreatic MCNs are classified as adenomas, borderline tumors, noninvasive adenocarcinomas, and invasive carcinomas. Zamboni et al. [11] classified a series of 56 MCNs of the pancreas as 22 adenomas, 12 borderline tumors, 6 noninvasive carcinomas, and 16 invasive carcinomas.

Pancreatic and ovarian MCNs show similar morphologic features and biologic behavior [11], such as malignancy correlated with multilocularity and papillary projections or mural nodules, and loss of OLS. Compagno and Oertel [5] believed that all pancreatic MCNs should be regarded as potentially malignant, regardless of the epithelial component, and that histology alone is not a definitive prospective indicator of behavior. However, pancreatic MCNs in general have an indolent clinical course and are less aggressive than conventional infiltrating pancreatic ductal adenocarcinomas. Based on the morphologic features and biologic behavior, such as malignancy correlated with multilocularity and papillary projections or mural nodules, pancreatic MCNs are similar to their ovarian counterparts [11].

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