Differential Diagnosis

Pancreatic MCNs were previously confused with intraductal papillary-mucinous neoplasms (IPMNs), because both tumors are mucin-producing cystic tumors. Massive mucin production is found in both, and papillary projection is a common histological characteristic. However, there are also many differences. MCNs and IPMNs differ sufficiently in clinical presentation, such as anatomic location, radiographic appearance and patient demographics. IPMNs are most frequently found in men in their sixties, originate in the head of the pancreas, and histologically are characterized by dilatation of the main or branch pancreatic ducts. Pancreatic MCNs occur mostly in middle-aged women, and are located in the body and tail of the pancreas. Moreover, the presence of OLS distinguishes MCNs from IPMNs.

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