Many studies on myofibroblasts in the pancreas have clarified that these cells play important roles in the pathogenesis of pancreatitis. Analysis of myofibroblast proliferation patterns in the pancreas can help our understanding of the mechanisms of various pancreatic diseases. Our results suggest that proliferation of myofibroblasts in the duct wall might represent a wound healing process of ductal injury or serve to prevent the elevation of intraductal pressure, while their proliferation in the parenchyma might be related to the inflammatory process of the parenchyma in various pathologic situations. Finally, how myofi-broblasts activate and become to be inactive cells remains to be clarified.
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