Solid pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasia of uncertain histogenesis, which usually occur in young females and is regarded as a tumor of low malignancy potential. We describe the histopathological features of four cases of this tumor and review the literature. All patients were female with ages ranging from 18 to 60 years (mean 35.2 years). Grossly, the tumors appeared as a solid cystic mass, frequently with hemorrhagic and necrotic areas; however, with a predominantly cystic formation in 1 case and of non-cystic type in 1 case. The histological findings of the tumor cells were relatively uniform, showing solid and pseudopapillary or pseudoglandular proliferation and having few mitotic figures or nuclear pleomorphism. On immunohistochemical examination, all cases were similar to those previously reported as SPTP. In addition, all tumors showed low a Ki-67 index (< 1.0% of all tumor cells). One of four cases proved to be metastatic to lymph nodes. Despite metastasis, the proliferating ability of the tumor cells was relatively low and this patient is alive with no evidence of recurrence since surgery. SPTPs have distinctive morphologic and biologic features; therefore, it may be difficult to evaluate the malignancy potential by histological and immunohistochemical examination.

Copyright © 2007 S. Karger AG, Basel

Solid pseudopapillary tumor of the pancreas (SPTP) is a rare form of pancreatic neoplasm, usually occurring in young females. With improvements of ultrasonography (US) and computed tomography (CT), the frequency of detection of this tumor is nowadays increasing. However, its etiology and pathogenesis are still unknown. Although SPTP shows relatively low aggressive behavior and a good prognosis, local recurrences and even metastases have been reported in a few cases. Therefore, this tumor is regarded as a neoplasia of low malignancy potential. We present here four cases of SPTP, including a case with lymph node metastasis, and review previously reported cases in order to clarify the pathological concept of this tumor.

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