Antimetabolites are a group of drugs that interfere with metabolite, which is a substance (such as an enzyme) that is necessary for cell metabolism. Common antimetabolites follow.


Sulfonamides or sulfa drugs are used to treat urinary tract infections and control infections in burn patients. These were among the first synthetic antimicrobial drugs used. Commonly used sulfonamides are:

• Silver sulfadiazine is used to control infections common in burn patients.

• TMP-SMZ is a combination of trimethoprim and sulfamethoxazole and is used to combat intestinal tract and urinary tract gram-negative pathogens.

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