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■ Figure 9-15 Bead array technology. Beads colored with distinct fluorescent dyes (upper left) are covalently attached to the probe sequences, each color of bead attached to a probe representing a specific locus. In a sequence-specific PCR, test DNA is amplified with tailed primers. The tailed PCR products are amplified in a second reaction to generate labeled amplicons that will bind to specific beads, according to the gene locus. The combination of bead label and the hybridized amplicon label reveals whether there is a mutant or normal allele at that locus.
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