Serous EIC An Immediate Precursor to Invasion

Serous endometrial intraepithelial carcinoma (serous EIC [29,53]) is a noninvasive form of papillary serous adenocarcinoma (54) (Fig. 6, Panel B). Serous EIC, seen in almost 90% of uteri with papillary serous carcinoma (53), is made up of cells identical to invasive papillary serous carcinoma in their cytology and in the presence of p53 mutation. It's most common presentation is thus a pattern of extension from the

coexisting invasive tumor. Occasionally, serous EIC is seen as the initial diagnostic manifestation of a noninvasive papillary serous adenocarcinoma (52). Isolated EIC is a lesion with intrinsic malignant behavior, as it has the capacity for peritoneal metastasis to abdominal sites (55). In this regard it cannot be considered a premalignant lesion, but rather an immediate precursor of the invasive form of disease.

0 0

Post a comment