P53 Polymorphism

Storey (9) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer, with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. These authors further noted that in the United Kingdom, individuals homozygous for the arginine allele were sevenfold more susceptible to HPV-associated tumorigenesis than proline/arginine heterozygote. Subsequent studies in different countries failed to unanimously confirm this association. This discrepancy in the result could be because of the small sample sizes investigated by different groups and the quality of DNA and controls used for the analysis.

Meta-analysis studies (10,11) showed a trend toward the ARG72ARG p53 polymorphism being associated with increased risk of developing cervical cancer; however, these data must be confirmed by larger studies.

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