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HE4/WFDC2, ovarian cancer early detection marker, 31

Her-2/neu, cervical cancer marker, 117, 118 ovarian cancer, amplification in ovarian carcinogenesis, 23 prognostic marker, 38 Hereditary nonpolyposis colorectal cancer syndrome (HNPCC), cardinal features, 197

endometrial cancer, age at diagnosis, 207 association, 195—197, 202, 205, 211 clinical characteristics, 206, 207 multiple primary cancers, 208, 209 surveillance and surgical prophylaxis, 209— 211

mismatch repair gene mutations, 179, 205 ovarian cancer risks, 178, 179, 207, 208 HIV, see Human immunodeficiency virus HLA-G, overexpression in ovarian carcinogenesis, 23 HNPCC, see Hereditary nonpolyposis colorectal cancer syndrome HPV, see Human papillomavirus Human immunodeficiency virus (HIV), human papillomavirus and cervical cancer interactions, 116 Human papillomavirus (HPV), see also Cervical cancer, adolescent biological vulnerability, 105, 106 cervical cancer association evidence, 125, 126 clearance versus oncogenic progression, 131—133, 140

DNA integration into host genome, 115

epidemiology, 127

genotypes, 125, 126

high-risk types in cervical cancer, 127

human immunodeficiency virus interactions, 116

infection mechanism, 130, 131

natural history in adolescents, 106, 107

oncoproteins, cell cycle effects, 114, 133 types and functions, 127—130, 140 prevalence by age, 104 sexual transmission, 103, 104, 126 squamous intraepithelial lesion, see Cervical cancer structure, 127 vaccination, prophylaxis, comparison of vaccines, 139 L1-based vaccines, 134—136 L2-based vaccines, 136, 138, 140 rationale, 134 therapeutic vaccines, combination approaches, 146 dendritic cell-based vaccines, 144, 145 DNA vaccines, 143, 144, 146 live vector-based vaccines, 140, 143, 146 peptide-based vaccines, 141, 142 prospects, 147, 148 RNA vaccines, 144 tumor cell-based vaccines, 145 Hydatidiform mole, see Gestational trophoblastic disease

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