D

DNA microarray, ovarian cancer marker development, 39

Doxorubicin, endometrial cancer management, 66 E

EGD, see Endometrial glandular dysplasia EIC, see Endometrial intraepithelial carcinoma Endometrial cancer, adenocarcinoma, histological classification, 53—56 hormonal risk modulation in type I, 83, 85 p53 mutations in type II, 74, 75, 85, 95, 202 preinvasive disease, see Endometrial glandular dysplasia; Endometrial hyperplasia; Endometrial intraepithelial carcinoma progression, endometroid adenocarcinoma, 64, 65 uterine papillary serous carcinoma, 65 prospects for study, 67, 68 PTEN mutations in type I, 74, 75, 83, 85, 92— 94, 202

types, 52, 53, 73—75, 92—95, 200—202 carcinogenesis, emergence of lesions, 79

endometrial intraepithelial carcinoma, see

Endometrial intraepithelial carcinoma preclinical phase, 78, 79 premalignant lesion features, 76, 77 prospects for study, 88 PTEN changes, 77, 78, 80, 202 clear cell carcinoma molecular genetics, 96, 97 epidemiology, 51, 52, 195 heredity, family history taking, 199 hereditary nonpolyposis colorectal cancer syndrome, age at diagnosis, 207 association, 195—197, 202, 205, 211 clinical characteristics, 206, 207 multiple primary cancers, 208, 209 surveillance and surgical prophylaxis, 209— 211

ovarian cancer with familial disease, 207, 208 pedigree analysis, 196, 198, 199 Stein—Leventhal syndrome, 212 syndromes, 75, 76 hormone relationships with molecular genetic alterations, 97, 98, 206 MLH1 microsatellite instability, 78, 79, 94, 202— 205

mouse models, 98 surveillance, 182

treatment of advanced and recurrent disease, 65—67 uterine cervical carcinoma distinction, 197—199

Endometrial glandular dysplasia (EGD), features and carcinogenesis, 87 Endometrial hyperplasia, carcinogenesis, 76 classification, 58—60 definition, 57, 58 diagnostic reproducibility, 60—63 Endometrial intraepithelial carcinoma (EIC), clinical outcome prediction, 83 diagnostic criteria, 80—83 histology, 64

molecular features, 80, 81 serous carcinoma association, 63, 64 serous endometrial intraepithelial carcinoma, 86, 87

Epidermal growth factor receptor, see Her-2/neu Epithelial trophoblastic tumor (ETT), pathogenesis, 163, 164

EPS, see Exaggerated placental site ETT, see Epithelial trophoblastic tumor Exaggerated placental site (EPS), pathogenesis, 162

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