Several reports have recently highlighted the biological and clinical role of cyclooxy-genase (COX)-2, the key enzyme in the conversion of arachidonic acid to prostaglandins, in the pathogenesis and natural history of human cancer (43). In particular, COX-2 overexpression is involved in the inhibition of apoptosis, increased metastatic potential and neoangiogenesis, and impairment of host immune responses. Moreover, COX-2 has been associated with parameters of tumor aggressiveness and unfavorable prognosis in several solid tumors including colorectal, breast, ovarian, and cervical cancer. Several reports have shown that high COX-2 expression in tumor cells characterizes cervical cancer patients with poor survival, regardless of the type of primary treatment (44,45). Moreover, COX-2 status could provide additional information to identify patients with cervical cancer with a poor chance of response to neoadjuvant treatment and unfavorable prognosis (46).

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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