Contents

Preface vii

Contributors xi

Color Plates xiii

I INTRODUCTION

1 The Cell Cycle and the Molecular Biology of Cancer 3

Giuseppina D'Andrilli, Alessandro Bovicelli, and Antonio Giordano

II OVARIAN CANCER

2 Ovarian Serous Carcinogenesis: A Proposed Model 17

Ie-Ming Shih and Robert J. Kurman

3 Molecular Markers in Epithelial Ovarian Cancer 29

Pat J. Morin

III ENDOMETRIAL CANCER

4 Introduction to Endometrial Cancer 51

Richard J. Zaino

5 Endometrial Carcinogenesis: An Integrated, Molecular, Histological, and Functional Model of a Dualistic Disease 73

George L. Mutter

6 Endometrial Carcinoma-Molecular Genetic Aspects 91

Lora Hedrick Ellenson

IV CERVICAL CANCER

7 Natural History of HPV Infection in Adolescents and Relationship to Cervical Cancer 103

Anna-Barbara Moscicki

8 Molecular Genetics of Cervical Cancer 113

Valeria Masciullo and Antonio Giordano

9 Prevention and Treatment of Cervical Cancer by Vaccination 125

V GESTATIONAL TROPHOBLASTIC DISEASE

10 Pathogenesis of Gestational Trophoblastic Lesions 157

Ie-Ming Shih and Robert J. Kurman

VI HEREDITARY ISSUES IN GYNECOLOGICAL CANCER

11 Hereditary Issues in Ovarian Cancer 169

Christina S. Chu and Stephen C. Rubin

12 Hereditary Factors in Endometrial Cancer 195

Henry T. Lynch, Murray Joseph Casey, Joseph A. Knezetic, Trudy G. Shaw, Jane F. Lynch, and Chhanda Bewtra

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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