Conclusions

Except for CA 125, which can be useful for monitoring relapse in ovarian cancer patients, there are currently no molecular markers appropriate for early detection of ovarian

Fig. 1. Current and future technology for detection and prognosis of ovarian cancer.

cancer in the general population or for prediction of outcome. The identification of such markers would clearly have a profound impact on ovarian cancer management and on the morbidity of this disease. Many promising avenues are currently being pursued, such as the identification of new targets from large-scale analysis as well as the investigation of known candidates (for example, kallikreins and p27 are particularly promising for diagnosis), alone or in combination. The field of proteomics is also likely to play a more prominent role in the future (see Fig. 1). It is hoped that molecular medicine will allow for earlier detection and better insight into treatment outcome, both of which would undoubtedly lead to a concomitant reduction in the number of ovarian cancer deaths.

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