Molecular genetic analysis in combination with histopathological features have provided key insights into the pathogenesis of endometrial carcinoma. The recent studies have supported a broad classification of endometrial carcinoma by documenting distinct molecular genetic profiles of the two most common histological types of the disease. These findings have not only elevated the understanding of this common malignancy of the female genital tract, they have provided the fundamentals for developing new diagnostic and treatment modalities. Finally, these studies have set the stage for the construction of a mouse model that will give us the opportunity to study this tumor in a dynamic in vivo model, where the relationship of molecular genetic alterations and hormones can be further elucidated.

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