Clinical Characteristics Of Ec In Lynch Syndrome

ECs occurring in the Lynch syndrome setting show some distinctive features. Unlike sporadic ECs hereditary EC occurs more commonly among younger women. Fifty-seven percent of hereditary ECs are diagnosed in women younger than 50 years of age. The average age of HNPCC-related EC is 48 years (range 27-72 years), compared with an average age of 55 years in sporadic EC (44). Sixty-one percent of EC in Lynch syndrome germline mutation carriers occurred with second primary CRCs, and 15% occurred with a third primary tumor (44).

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