C

CA 125, ovarian cancer, early detection marker, 30, 31, 181 prognostic marker, 38 p-Catenin, cervical cancer marker, 116 endometrial cancer mutations, 79 CDK, see Cyclin-dependent kinase Cell cycle, alterations in malignant transformation, 5 G1/S phase alterations in cancer cyclin D1, 6 cyclin D2, 7 cyclin D3, 7

cyclin-dependent kinase inhibitors, 7, 8 cyclin-dependent kinase-4, 7 cyclin E, 6 G2/M phase alterations in cancer, 9, 10 human papillomavirus oncoprotein effects, 114, 133

p53 pathway in cancer, 8 prospects for study, 10

regulation, 3—5

retinoblastoma protein pathway in cancer, 8, 9 Cervical cancer, see also Human papillomavirus, markers, p-catenin, 116 cyclooxygenase-2, 118 FHIT, 117p16, 117 Her-2/neu, 117, 118 keratins, 118—119 Ki-67, 117

matrix metalloproteinases, 119 p53 polymorphisms, 114, 115 screening, 107, 108 squamous intraepithelial lesion, high-grade, 104, 113, 132, 133 low-grade, 104, 105, 108, 109, 113, 132 natural history in adolescents, 106, 107 triage, 108, 109 Choriocarcinoma, pathogenesis, 161, 162 Chorionic-type intermediate trophoblastic cell, features, 159 Cisplatin, endometrial cancer management, 66 CKIs, see Cyclin-dependent kinase inhibitors Colon cancer, see also Hereditary nonpolyposis colorectal cancer syndrome, surveillance, 182 COX-2, see Cyclooxygenase-2 Cyclin D1, cancer alterations, 6 ovarian cancer prognostic marker, 37 Cyclin D2, cancer alterations, 7 Cyclin D3, cancer alterations, 7 Cyclin-dependent kinase (CDK), cancer alterations, 7 cell cycle control, 3—5 Cyclin-dependent kinase inhibitors (CKIs), cancer alterations, 7, 8 cell cycle control, 3 ovarian cancer prognostic markers, p16, 36 p21, 36 p27, 36 Cyclin E, cancer alterations, 6 ovarian cancer prognostic marker, 37 Cyclooxygenase-2 (COX-2), cervical cancer marker, 118 ovarian cancer chemoprophylaxis, 183, 184 CYP1B1, polymorphisms in endometrial cancer, 206 Cytotrophoblast, features, 158

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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