Angiogenesis And Cervical Cancer

Angiogenesis is the development of new blood vessels from preexisting capillaries and is a critical step in the growth, progression, and metastasis of tumors. The degree of angio-genesis has also been associated with the prognosis of neoplasm. Several studies suggest that angiogenesis might be involved in the development and progression of cervical tumors and that microvessel density could represent an important clinical prognostic factor (54).

Despite the small number of studies, the expression of several angiogenetic factors seems to play a promising role in cervical tumors. Vascular endothelial growth factor, basic fibroblast growth factor, and transforming growth factor (TGFp)1 correlate with the malignant transformation of uterine cervix (55). Whereas CD34, an antigen present in endothelial cells is a very sensitive marker for vascular tumors whose expression in early cervical squamous cell carcinoma (Ib-IIa) is associated with pathoanatomical features indicative of poor prognosis (56).

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