Mechanism of Infection

Pathogenesis Human Papilloma Virus

The pathogenesis of cervical cancer is initiated by HPV infection of the cervical epithelium during sexual intercourse. Virions penetrate the epithelium through microabrasions and invade the basal cells of stratified epithelia of the uterine cervical transformation zone, establishing their genomes as a stable, low copy number of viral episomes (50-100 genomes per cell) in an initial burst of replication (Fig. 3 see Color Fig. 3 (Color Plate 4, following p. 50). HPV life cycle. The pathogenesis...

Type I And Type Ii Tumors Are Characterized By Unique Molecular Features

Mouse Ovarian Tumor

Because serous carcinoma is the most common type of ovarian carcinoma, this discussion is focussed on low- and high-grade serous carcinomas as they represent the prototypes of type I and type II carcinomas, respectively. Both low- and high-grade serous carcinomas can be distinguished by unique molecular genetic alterations. Among Precursors and Molecular Genetic Alterations of Type I and Type II Tumors of the Ovary Type I tumors Precursorsa genetic alterations Malignant Brenner transitional...