By Jasodhara Ray, Heather K. Raymon, and Fred H. Gage Introduction
The mechanisms for generation of the diversified cell types of the central nervous system (CNS) from the homogeneous population of neuroepithelial cells are not well understood. Proliferating cells can be found in different brain regions at specified times during development. In general, it is thought that this developmental wave of neurogenesis ends with a departure from the cell cycle and subsequent cellular differentiation. Observations have shown that the immature CNS is not the only site for cellular proliferation
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